Dissolution Calculation Software Free Download

The dissolution time points for both the profiles should be the same, e.g., for immediate release products 15, 30, 45 and 60 minutes, for extended release products 1, 2, 3, 5 and 8 hours. The dissolution measurements of the two products (test and reference, pre- and post- change, two strengths) should be made under the same test conditions.For circumstances where wide variability is observed, or a statistical evaluation of f2 metric is desired, a bootstrap approach to calculate a confidence interval can be performed.To use mean data, the % coefficient of variation at the earlier point should not be more than 20% and at other time points should not be more than 10%. Mean dissolution values can be used to estimate the similarity factor, f2. At least 12 units should be used for each profile determination.

FDA has set a public standard of f2 value between 50-100 to indicate similarity between two dissolution profiles. An average difference of 10% at all measured time points results in a f2 value of 50. When the two profiles are identical, f2=100. For more information related to the Gibbs Phase Matrix, see our tutorials. PH, CO2, fixed ions, gases, solids and redox can all be set from one tool. The Calculation Wizards now give you greater control over system setup. You may fit either the mean values of the replicate data or, using the replicate data format, the replicate data itself. You may also download the custom curve fit library Release.exe to fit various equations to your dissolution data. Download the self-extracting file Dissolution Calculator.exe and double-click on it to obtain this notebook. Although primarily designed for geothermal reservoir studies and high-level nuclear waste isolation, TOUGH3 can be applied to a wider range of problems Software Read More ». Below you will find a quick summary of the TOUGH Software Suite, with links to more detailed information on each: TOUGH3 is the basic simulator for nonisothermal multiphase flow in fractured porous media. FEATURES AND THEORETICAL BACKGROUND KinetDS is software for curve fitting, designed particularly to describe the cumulative dissolution curve by a simple equation or set of equations. Graphical user interface (GUI), a high level of software automation, and free availability for commercial and noncommercial use.

Dissolution Calculation Software Free Download